Repeated doses of porcine secretin did not improve symptoms, language, or cognitive functioning in children with autism or autism spectrum disorder.

Main outcome measures Assessment of symptoms of autism (Autism Behaviour Checklist and Treatment/Side Effect Behaviour Scale by parents and ADOS-G by clinicians), language (Preschool Language Scale III [PLS-3]) and ADOS-G), visual spatial attention task, and physiological and/or gastrointestinal (GI) symptoms (parent questionnaires). Cognitive function (Leiter International Performance Scale-Revised and Vineland Adaptive Behavior Scales) was assessed at baseline and final follow-up.